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p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction
HDM2 and HDMX are two homologs essential for controlling p53 tumor suppressor activity under normal conditions. Both proteins bind different sites on the p53 N‐terminus, and while HDM2 has E3 ubiquitin ligase activity towards p53, HDMX does not. Nevertheless, HDMX is required for p53 polyubiquitinat...
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| Gepubliceerd in: | Protein Sci |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
John Wiley and Sons Inc.
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5916125/ https://ncbi.nlm.nih.gov/pubmed/29524278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3405 |
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