Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions

HDM2 and HDMX are key negative regulatory factors of the p53 tumor suppressor under normal conditions by promoting its degradation or preventing its trans activity, respectively. It has more recently been shown that both proteins can also act as positive regulators of p53 after DNA damage. This invo...

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Publicado no:Mol Cell Biol
Main Authors: Medina-Medina, Ixaura, García-Beltrán, Paola, de la Mora-de la Mora, Ignacio, Oria-Hernández, Jesús, Millot, Guy, Fahraeus, Robin, Reyes-Vivas, Horacio, Sampedro, José G., Olivares-Illana, Vanesa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968209/
https://ncbi.nlm.nih.gov/pubmed/27215386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00113-16
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