Hdm2 is an Ubiquitin Ligase of Ku70 -Akt Promotes Cell Survival by Inhibiting Hdm2-dependent Ku70 Destabilization

Previously, we reported that Ku70 binds and inhibits Bax activity in the cytosol, and that ubiquitin-dependent proteolysis of cytosolic Ku70 facilitates Bax-mediated apoptosis. We found that Hdm2 (Human Homologue of Murine Double Minute) has an ability to ubiquitinate Ku70 and that Hdm2 overexpressi...

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Bibliographische Detailangaben
Hauptverfasser: Gama, Vivian, Gomez, Jose A., Mayo, Lindsey D., Jackson, Mark W., Danielpour, David, Song, Kyung, Haas, Arthur L., Laughlin, Mary J., Matsuyama, Shigemi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669846/
https://ncbi.nlm.nih.gov/pubmed/19247369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.6
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