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Hdm2 is an Ubiquitin Ligase of Ku70 -Akt Promotes Cell Survival by Inhibiting Hdm2-dependent Ku70 Destabilization
Previously, we reported that Ku70 binds and inhibits Bax activity in the cytosol, and that ubiquitin-dependent proteolysis of cytosolic Ku70 facilitates Bax-mediated apoptosis. We found that Hdm2 (Human Homologue of Murine Double Minute) has an ability to ubiquitinate Ku70 and that Hdm2 overexpressi...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2009
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669846/ https://ncbi.nlm.nih.gov/pubmed/19247369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.6 |
| Tagiau: |
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