Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing

Chemically engineered small molecules targeting specific genomic sequences play an important role in drug development research. Pyrrole-imidazole polyamides (PIPs) are a group of molecules that can bind to the DNA minor-groove and can be engineered to target specific sequences. Their biological effe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Chandran, Anandhakumar, Syed, Junetha, Taylor, Rhys D., Kashiwazaki, Gengo, Sato, Shinsuke, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Chemical Biology and Nucleic Acid Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872120/
https://ncbi.nlm.nih.gov/pubmed/27098039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw283
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