Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

The influential role of the epigenome in orchestrating genome-wide transcriptional activation instigates the demand for the artificial genetic switches with distinct DNA sequence recognition. Recently, we developed a novel class of epigenetically active small molecules called SAHA-PIPs by conjugatin...

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Main Authors: Pandian, Ganesh N., Taniguchi, Junichi, Junetha, Syed, Sato, Shinsuke, Han, Le, Saha, Abhijit, AnandhaKumar, Chandran, Bando, Toshikazu, Nagase, Hiroki, Vaijayanthi, Thangavel, Taylor, Rhys D., Sugiyama, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900999/
https://ncbi.nlm.nih.gov/pubmed/24457603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03843
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