Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing

Chemically engineered small molecules targeting specific genomic sequences play an important role in drug development research. Pyrrole-imidazole polyamides (PIPs) are a group of molecules that can bind to the DNA minor-groove and can be engineered to target specific sequences. Their biological effe...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Chandran, Anandhakumar, Syed, Junetha, Taylor, Rhys D., Kashiwazaki, Gengo, Sato, Shinsuke, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Chemical Biology and Nucleic Acid Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872120/
https://ncbi.nlm.nih.gov/pubmed/27098039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw283
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