Submolecular dissection reveals strong and specific binding of polyamide–pyridostatin conjugates to human telomere interface

To modulate biological functions, G-quadruplexes in genome are often non-specifically targeted by small molecules. Here, specificity is increased by targeting both G-quadruplex and its flanking duplex DNA in a naturally occurring dsDNA–ssDNA telomere interface using polyamide (PA) and pyridostatin (...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Mandal, Shankar, Kawamoto, Yusuke, Yue, Zhizhou, Hashiya, Kaori, Cui, Yunxi, Bando, Toshikazu, Pandey, Shankar, Hoque, Mohammed Enamul, Hossain, Mohammad Akter, Sugiyama, Hiroshi, Mao, Hanbin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468309/
https://ncbi.nlm.nih.gov/pubmed/30820532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz135
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