Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants

N-methylpyrrole (Py)-N-methylimidazole (Im) polyamides are small organic molecules that bind to DNA with sequence specificity and can be used as synthetic DNA-binding ligands. In this study, five hairpin eight-ring Py–Im polyamides 1–5 with different number of Im rings were synthesized, and their bi...

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Detalhes bibliográficos
Main Authors: Han, Yong-Woon, Matsumoto, Tomoko, Yokota, Hiroaki, Kashiwazaki, Gengo, Morinaga, Hironobu, Hashiya, Kaori, Bando, Toshikazu, Harada, Yoshie, Sugiyama, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526260/
https://ncbi.nlm.nih.gov/pubmed/23042247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks897
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