DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

TEN-ELEVEN-TRANSLOCATION-2 (TET2) and DNA-METHYLTRANSFERASE-3A (DNMT3A), both encoding proteins involved in regulating DNA methylation, are mutated in hematological malignancies affecting both myeloid and lymphoid lineages. We previously reported an association of TET2 and DNMT3A mutations in progen...

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書誌詳細
出版年:Leukemia
主要な著者: Scourzic, Laurianne, Couronné, Lucile, Pedersen, Marianne T., Della Valle, Véronique, Diop, M’boyba, Mylonas, Elena, Calvo, Julien, Mouly, Enguerran, Lopez, Cécile K., Martin, Nadine, Fontenay, Michaëla, Bender, Ambre, Guibert, Sylvain, Dubreuil, Patrice, Dessen, Philippe, Droin, Nathalie, Pflumio, Françoise, Weber, Michael, Gaulard, Philippe, Helin, Kristian, Mercher, Thomas, Bernard, Olivier A.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869893/
https://ncbi.nlm.nih.gov/pubmed/26876596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.29
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