B-cell tumor development in Tet2-deficient mice

The TET2 gene encodes an α-ketoglutarate–dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies. TET2 somatic mutations are also id...

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Vydáno v:Blood Adv
Hlavní autoři: Mouly, Enguerran, Ghamlouch, Hussein, Della-Valle, Veronique, Scourzic, Laurianne, Quivoron, Cyril, Roos-Weil, Damien, Pawlikowska, Patrycja, Saada, Véronique, Diop, M’Boyba K., Lopez, Cécile K., Fontenay, Michaela, Dessen, Philippe, Touw, Ivo P., Mercher, Thomas, Aoufouchi, Said, Bernard, Olivier A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873234/
https://ncbi.nlm.nih.gov/pubmed/29581109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017014118
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