DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

TEN-ELEVEN-TRANSLOCATION-2 (TET2) and DNA-METHYLTRANSFERASE-3A (DNMT3A), both encoding proteins involved in regulating DNA methylation, are mutated in hematological malignancies affecting both myeloid and lymphoid lineages. We previously reported an association of TET2 and DNMT3A mutations in progen...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Scourzic, Laurianne, Couronné, Lucile, Pedersen, Marianne T., Della Valle, Véronique, Diop, M’boyba, Mylonas, Elena, Calvo, Julien, Mouly, Enguerran, Lopez, Cécile K., Martin, Nadine, Fontenay, Michaëla, Bender, Ambre, Guibert, Sylvain, Dubreuil, Patrice, Dessen, Philippe, Droin, Nathalie, Pflumio, Françoise, Weber, Michael, Gaulard, Philippe, Helin, Kristian, Mercher, Thomas, Bernard, Olivier A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869893/
https://ncbi.nlm.nih.gov/pubmed/26876596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.29
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