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Polarized localization of voltage-gated Na(+) channels is regulated by concerted FGF13 and FGF14 action

Clustering of voltage-gated sodium channels (VGSCs) within the neuronal axon initial segment (AIS) is critical for efficient action potential initiation. Although initially inserted into both somatodendritic and axonal membranes, VGSCs are concentrated within the axon through mechanisms that include...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Pablo, Juan Lorenzo, Wang, Chaojian, Presby, Matthew M., Pitt, Geoffrey S.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868475/
https://ncbi.nlm.nih.gov/pubmed/27044086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521194113
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