Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

Protein–protein interactions (PPI) offer unexploited opportunities for CNS drug discovery and neurochemical probe development. Here, we present ZL181, a novel peptidomimetic targeting the PPI interface of the voltage-gated Na(+) channel Nav1.6 and its regulatory protein fibroblast growth factor 14 (...

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Udgivet i:ACS Chem Neurosci
Main Authors: Ali, Syed R., Liu, Zhiqing, Nenov, Miroslav N., Folorunso, Oluwarotimi, Singh, Aditya, Scala, Federico, Chen, Haiying, James, T. F., Alshammari, Musaad, Panova-Elektronova, Neli I., White, Mark Andrew, Zhou, Jia, Laezza, Fernanda
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033619/
https://ncbi.nlm.nih.gov/pubmed/29359916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00399
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