Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions

The voltage-gated sodium (Nav) channel is the molecular determinant of action potential in neurons. Protein-protein interactions (PPI) between the intracellular Nav1.6 C-tail and its regulatory protein fibroblast growth factor 14 (FGF14) provide an ideal and largely untapped opportunity for developm...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Liu, Zhiqing, Wadsworth, Paul, Singh, Aditya K., Chen, Haiying, Wang, Pingyuan, Folorunso, Oluwarotimi, Scaduto, Pietro, Ali, Syed R., Laezza, Fernanda, Zhou, Jia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748043/
https://ncbi.nlm.nih.gov/pubmed/30587448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.12.031
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