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Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor
[Image: see text] For a subpopulation of acute myeloid leukemia (AML) patients, the mutationally activated tyrosine kinase FLT3, has emerged as a promising target for therapy. The development of drug resistance due to mutation is a growing concern for mutant FLT3 inhibitors, such as PKC412, Quizarti...
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| Publicado no: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2016
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867484/ https://ncbi.nlm.nih.gov/pubmed/27190596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00498 |
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