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Discovery and Characterization of Novel Mutant FLT3 Kinase Inhibitors

For a subpopulation of acute myeloid leukemia (AML) patients, the constitutively activated tyrosine kinase, mutant FLT3, has emerged as a promising target for therapy. The development of drug resistance, however, is a growing concern for mutant FLT3 inhibitors, such as PKC412. Potential therapeutic...

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書誌詳細
主要な著者: Weisberg, Ellen, Geun Choi, Hwan, Barrett, Rosemary, Zhou, Wenjun, Zhang, Jianming, Ray, Arghya, Nelson, Erik A., Jiang, Jingrui, Moreno, Daisy, Stone, Richard, Galinsky, Ilene, Fox, Edward, Adamia, Sophia, Kung, Andrew L., Gray, Nathanael S., Griffin, James D.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967795/
https://ncbi.nlm.nih.gov/pubmed/20807780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0232
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