Discovery and Characterization of Novel Mutant FLT3 Kinase Inhibitors

For a subpopulation of acute myeloid leukemia (AML) patients, the constitutively activated tyrosine kinase, mutant FLT3, has emerged as a promising target for therapy. The development of drug resistance, however, is a growing concern for mutant FLT3 inhibitors, such as PKC412. Potential therapeutic...

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Detalhes bibliográficos
Main Authors: Weisberg, Ellen, Geun Choi, Hwan, Barrett, Rosemary, Zhou, Wenjun, Zhang, Jianming, Ray, Arghya, Nelson, Erik A., Jiang, Jingrui, Moreno, Daisy, Stone, Richard, Galinsky, Ilene, Fox, Edward, Adamia, Sophia, Kung, Andrew L., Gray, Nathanael S., Griffin, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967795/
https://ncbi.nlm.nih.gov/pubmed/20807780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0232
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