Reversible Resistance Induced by FLT3 Inhibition: A Novel Resistance Mechanism in Mutant FLT3-Expressing Cells

OBJECTIVES: Clinical responses achieved with FLT3 kinase inhibitors in acute myeloid leukemia (AML) are typically transient and partial. Thus, there is a need for identification of molecular mechanisms of clinical resistance to these drugs. In response, we characterized MOLM13 AML cell lines made re...

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Main Authors: Weisberg, Ellen, Ray, Arghya, Nelson, Erik, Adamia, Sophia, Barrett, Rosemary, Sattler, Martin, Zhang, Chengsheng, Daley, John F., Frank, David, Fox, Edward, Griffin, James D.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182213/
https://ncbi.nlm.nih.gov/pubmed/21980431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025351
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