Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor

[Image: see text] For a subpopulation of acute myeloid leukemia (AML) patients, the mutationally activated tyrosine kinase FLT3, has emerged as a promising target for therapy. The development of drug resistance due to mutation is a growing concern for mutant FLT3 inhibitors, such as PKC412, Quizarti...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Hatcher, John M., Weisberg, Ellen, Sim, Taebo, Stone, Richard M., Liu, Suiyang, Griffin, James D., Gray, Nathanael S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867484/
https://ncbi.nlm.nih.gov/pubmed/27190596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00498
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