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Rapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-l-cysteine

The goals of this study were to evaluate the effects of ionizing radiation on apical junctions in colonic epithelium and mucosal barrier function in mice in vivo. Adult mice were subjected to total body irradiation (4 Gy) with or without N-acetyl-l-cysteine (NAC) feeding for 5 days before irradiatio...

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Detalles Bibliográficos
Publicado en:Am J Physiol Gastrointest Liver Physiol
Main Authors: Shukla, Pradeep K., Gangwar, Ruchika, Manda, Bhargavi, Meena, Avtar S., Yadav, Nikki, Szabo, Erzsebet, Balogh, Andrea, Lee, Sue Chin, Tigyi, Gabor, Rao, RadhaKrishna
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867328/
https://ncbi.nlm.nih.gov/pubmed/26822914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00314.2015
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