Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of...

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Bibliographic Details
Published in:	PLoS Biol
Main Authors:	Veit, Guido, Oliver, Kathryn, Apaja, Pirjo M., Perdomo, Doranda, Bidaud-Meynard, Aurélien, Lin, Sheng-Ting, Guo, Jingyu, Icyuz, Mert, Sorscher, Eric J., Hartman, John L., Lukacs, Gergely L.
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2016
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4864299/ https://ncbi.nlm.nih.gov/pubmed/27168400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002462
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Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

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