Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of...

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Detalles Bibliográficos
Publicado en:PLoS Biol
Main Authors: Veit, Guido, Oliver, Kathryn, Apaja, Pirjo M., Perdomo, Doranda, Bidaud-Meynard, Aurélien, Lin, Sheng-Ting, Guo, Jingyu, Icyuz, Mert, Sorscher, Eric J., Hartman, John L., Lukacs, Gergely L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864299/
https://ncbi.nlm.nih.gov/pubmed/27168400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002462
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