Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of...

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Publicat a:PLoS Biol
Autors principals: Veit, Guido, Oliver, Kathryn, Apaja, Pirjo M., Perdomo, Doranda, Bidaud-Meynard, Aurélien, Lin, Sheng-Ting, Guo, Jingyu, Icyuz, Mert, Sorscher, Eric J., Hartman, John L., Lukacs, Gergely L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864299/
https://ncbi.nlm.nih.gov/pubmed/27168400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002462
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