Clofazimine Contributes Sustained Antimicrobial Activity after Treatment Cessation in a Mouse Model of Tuberculosis Chemotherapy

Experimental and clinical studies have indicated that the antileprosy drug clofazimine may contribute treatment-shortening activity when included in tuberculosis treatment regimens. Clofazimine accumulates to high levels in tissues, has a long half-life, and remains in the body for months after admi...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Swanson, Rosemary V., Ammerman, Nicole C., Ngcobo, Bongani, Adamson, John, Moodley, Chivonne, Dorasamy, Afton, Moodley, Sashen, Mgaga, Zinhle, Bester, Linda A., Singh, Sanil D., Almeida, Deepak V., Grosset, Jacques H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862514/
https://ncbi.nlm.nih.gov/pubmed/26926638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00177-16
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