Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase

Constitutive activation of the mammalian target of rapamycin complex 1 and S6 kinase (mTORC1→ S6K) attenuates insulin-stimulated Akt activity in certain tumors in part through “feedback” phosphorylation of the upstream insulin receptor substrate 1 (IRS1). However, the significance of this mechanism...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Copps, Kyle D., Hançer, Nancy J., Qiu, Wei, White, Morris F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861431/
https://ncbi.nlm.nih.gov/pubmed/26846849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.714915
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