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Irs1 Serine 307 Promotes Insulin Sensitivity in Mice
Phosphorylation of the insulin receptor substrates (Irs) on serine residues—typified by Ser307 of rodent Irs1—is thought to mediate insulin resistance. To determine whether Ser307 negatively regulates Irs1 in vivo, we generated knock-in mice in which Ser307 (human Ser312) was replaced with alanine (...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314336/ https://ncbi.nlm.nih.gov/pubmed/20074531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.11.003 |
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