Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation

IRS1 and IRS2 are key substrates of the insulin receptor tyrosine kinase. Mass spectrometry reveals more than 50 phosphorylated IRS1 serine and threonine residues (Ser(P)/Thr(P) residues) in IRS1 from insulin-stimulated cells or human tissues. We investigated a subset of IRS1 Ser(P)/Thr(P) residues...

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Hauptverfasser: Hançer, Nancy J., Qiu, Wei, Cherella, Christine, Li, Yedan, Copps, Kyle D., White, Morris F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007441/
https://ncbi.nlm.nih.gov/pubmed/24652289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554162
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