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Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase
Constitutive activation of the mammalian target of rapamycin complex 1 and S6 kinase (mTORC1→ S6K) attenuates insulin-stimulated Akt activity in certain tumors in part through “feedback” phosphorylation of the upstream insulin receptor substrate 1 (IRS1). However, the significance of this mechanism...
Sparad:
| I publikationen: | J Biol Chem |
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| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4861431/ https://ncbi.nlm.nih.gov/pubmed/26846849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.714915 |
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