Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters

ATP-Binding Cassette transporters are involved in the efflux of xenobiotic compounds and are responsible for decreasing drug accumulation in multidrug resistant (MDR) cells. Discovered by structure-based virtual screening algorithms, bafetinib, a Bcr-Abl/Lyn tyrosine kinase inhibitor, was found to h...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhang, Yun-Kai, Zhang, Guan-Nan, Wang, Yi-Jun, Patel, Bhargav A., Talele, Tanaji T., Yang, Dong-Hua, Chen, Zhe-Sheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860574/
https://ncbi.nlm.nih.gov/pubmed/27157787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25694
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