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Conformational control of DNA target cleavage by CRISPR–Cas9
Cas9 is an RNA-guided DNA endonuclease that targets foreign DNA for destruction as part of a bacterial adaptive immune system mediated by CRISPR (clustered regularly interspaced short palindromic repeats)(1,2). Together with single-guide RNAs (sgRNA)(3), Cas9 also functions as a powerful genome engi...
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| 出版年: | Nature |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4859810/ https://ncbi.nlm.nih.gov/pubmed/26524520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15544 |
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