Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease

Selective neuronal vulnerability is characteristic of most degenerative disorders of the CNS, yet mechanisms underlying this phenomenon remain poorly characterized. Many forms of cerebellar degeneration exhibit an anterior-to-posterior gradient of Purkinje cell loss including Niemann-Pick type C1 (N...

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Vydáno v:PLoS Genet
Hlavní autoři: Chung, Chan, Elrick, Matthew J., Dell’Orco, James M., Qin, Zhaohui S., Kalyana-Sundaram, Shanker, Chinnaiyan, Arul M., Shakkottai, Vikram G., Lieberman, Andrew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859571/
https://ncbi.nlm.nih.gov/pubmed/27152617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006042
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