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Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration

Pathways regulating neuronal vulnerability are poorly understood, yet are central to identifying therapeutic targets for degenerative neurological diseases. Here, we characterize mechanisms underlying neurodegeneration in Niemann-Pick type C (NPC) disease, a lysosomal storage disorder characterized...

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Bibliografske podrobnosti
Main Authors: Elrick, Matthew J., Pacheco, Chris D., Yu, Ting, Dadgar, Nahid, Shakkottai, Vikram G., Ware, Christopher, Paulson, Henry L., Lieberman, Andrew P.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816612/
https://ncbi.nlm.nih.gov/pubmed/20007718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp552
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