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Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration

Pathways regulating neuronal vulnerability are poorly understood, yet are central to identifying therapeutic targets for degenerative neurological diseases. Here, we characterize mechanisms underlying neurodegeneration in Niemann-Pick type C (NPC) disease, a lysosomal storage disorder characterized...

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Detalles Bibliográficos
Main Authors: Elrick, Matthew J., Pacheco, Chris D., Yu, Ting, Dadgar, Nahid, Shakkottai, Vikram G., Ware, Christopher, Paulson, Henry L., Lieberman, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816612/
https://ncbi.nlm.nih.gov/pubmed/20007718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp552
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