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Tau deletion exacerbates the phenotype of Niemann–Pick type C mice and implicates autophagy in pathogenesis
Hyperphosphorylation and aggregation of the microtubule-binding protein tau characterize a diverse array of neurodegenerative disorders. Most of these lack mutations in the encoding MAPT gene, and the role of tau in disease pathogenesis remains controversial. Among these tauopathies is Niemann–Pick...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2009
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646181/ https://ncbi.nlm.nih.gov/pubmed/19074461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn423 |
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