Laddar...

Impaired proteolysis underlies autophagic dysfunction in Niemann–Pick type C disease

Niemann–Pick type C disease (NPC) is a childhood onset neurodegenerative disorder arising from lipid-trafficking defects caused by mutations in the NPC1 or NPC2 gene. Marked accumulation of autophagosomes is a prominent feature of NPC cells, yet a detailed understanding of the disease-associated alt...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Elrick, Matthew J., Yu, Ting, Chung, Chan, Lieberman, Andrew P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607480/
https://ncbi.nlm.nih.gov/pubmed/22872701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds324
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!