Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis

Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experienced by the f...

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Udgivet i:Sci Rep
Main Authors: Rathan, Swetha, Ankeny, Casey J., Arjunon, Sivakkumar, Ferdous, Zannatul, Kumar, Sandeep, Fernandez Esmerats, Joan, Heath, Jack M., Nerem, Robert M., Yoganathan, Ajit P., Jo, Hanjoong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858741/
https://ncbi.nlm.nih.gov/pubmed/27151744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25397
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