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miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification

miR-214 has been recently found to be significantly downregulated in calcified human aortic valves (AVs). ER stress, especially the ATF4-mediated pathway, has also been shown to be significantly upregulated in calcific AV disease. Since elevated cyclic stretch is one of the major mechanical stimuli...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Ann Biomed Eng
Main Authors: Salim, Md Tausif, Esmerats, Joan Fernández, Arjunon, Sivakkumar, Villa-Roel, Nicolas, Nerem, Robert M., Jo, Hanjoong, Yoganathan, Ajit P.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416061/
https://ncbi.nlm.nih.gov/pubmed/30671754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10439-019-02206-3
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