Disturbed flow increases UBE2C via loss of miR-483-3p, inducing aortic valve calcification by the HIF1α pathway in endothelial cells

OBJECTIVE: Calcific aortic valve disease (CAVD), characterized by aortic valve (AV) sclerosis and calcification, is a major cause of death in the aging population; however, there are no effective medical therapies other than valve replacement. AV calcification preferentially occurs on the fibrosa-si...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Esmerats, Joan Fernandez, Villa-Roel, Nicolas, Kumar, Sandeep, Gu, Lina, Salim, Md Tausif, Ohh, Michael, Taylor, W. Robert, Nerem, Robert M., Yoganathan, Ajit P., Jo, Hanjoong
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393167/
https://ncbi.nlm.nih.gov/pubmed/30602302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.312233
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