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Disturbed flow increases UBE2C via loss of miR-483-3p, inducing aortic valve calcification by the HIF1α pathway in endothelial cells
OBJECTIVE: Calcific aortic valve disease (CAVD), characterized by aortic valve (AV) sclerosis and calcification, is a major cause of death in the aging population; however, there are no effective medical therapies other than valve replacement. AV calcification preferentially occurs on the fibrosa-si...
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| Vydáno v: | Arterioscler Thromb Vasc Biol |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6393167/ https://ncbi.nlm.nih.gov/pubmed/30602302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.312233 |
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