Opposing Roles of the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) and TREM-like Transcript 2 (TREML2) in Microglia Activation

Mutations in TREM2, which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β (Aβ), are genetically linked to increased risk for late-onset Alzheimer’s disease (AD). Interestingly, a missense variant in TREM-like transcript 2 (TREML2), a s...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Zheng, Honghua, Liu, Chia-Chen, Atagi, Yuka, Chen, Xiao-Fen, Jia, Lin, Yang, Longyu, He, Wencan, Zhang, Xilin, Kang, Silvia S., Rosenberry, Terrone L., Fryer, John D., Zhang, Yun-Wu, Xu, Huaxi, Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857884/
https://ncbi.nlm.nih.gov/pubmed/27143430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2016.03.004
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