mTORC2 critically regulates renal potassium handling

The mTOR pathway orchestrates cellular homeostasis. The rapamycin-sensitive mTOR complex (mTORC1) in the kidney has been widely studied; however, mTORC2 function in renal tubules is poorly characterized. Here, we generated mice lacking mTORC2 in the distal tubule (Rictor(fl/fl) Ksp-Cre mice), which...

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Vydáno v:J Clin Invest
Hlavní autoři: Grahammer, Florian, Nesterov, Viatcheslav, Ahmed, Azaz, Steinhardt, Frederic, Sandner, Lukas, Arnold, Frederic, Cordts, Tomke, Negrea, Silvio, Bertog, Marko, Ruegg, Marcus A., Hall, Michael N., Walz, Gerd, Korbmacher, Christoph, Artunc, Ferruh, Huber, Tobias B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855939/
https://ncbi.nlm.nih.gov/pubmed/27043284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80304
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