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A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

It is well-established that widespread transcriptional changes accompany the onset and progression of Alzheimer’s disease. Because of the multifactorial nature of this neurodegenerative disorder and its complex relationship with aging, however, it remains unclear whether such changes are the result...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Ciryam, Prajwal, Kundra, Rishika, Freer, Rosie, Morimoto, Richard I., Dobson, Christopher M., Vendruscolo, Michele
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855616/
https://ncbi.nlm.nih.gov/pubmed/27071083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516604113
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