A metastable subproteome underlies inclusion formation in muscle proteinopathies

Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and form a metastable subproteome. It is not yet clear, however, whether th...

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Опубликовано в: :Acta Neuropathol Commun
Главные авторы: Ciryam, Prajwal, Antalek, Matthew, Cid, Fernando, Tartaglia, Gian Gaetano, Dobson, Christopher M., Guettsches, Anne-Katrin, Eggers, Britta, Vorgerd, Matthias, Marcus, Katrin, Kley, Rudolf A., Morimoto, Richard I., Vendruscolo, Michele, Weihl, Conrad C.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891963/
https://ncbi.nlm.nih.gov/pubmed/31796104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0853-9
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