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Dok-1 Negatively Regulates Platelet Integrin αIIbβ3 Outside-in Signaling and Inhibits Thrombosis in Mice

Adaptor proteins play a critical role in the assembly of signaling complexes after engagement of platelet receptors by agonists such as collagen, ADP and thrombin. Recently, using proteomics, the Dok (downstream of tyrosine kinase) adapter proteins were identified in human and mouse platelets. In vi...

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Dades bibliogràfiques
Publicat a:Thromb Haemost
Autors principals: Niki, Masaru, Nayak, Manasa K., Jin, Hong, Bhasin, Neha, Plow, Edward F., Pandolfi, Pier Paolo, Rothman, Paul B., Chauhan, Anil K., Lentz, Steven R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854776/
https://ncbi.nlm.nih.gov/pubmed/26790499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH15-05-0373
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