Dok-1 Negatively Regulates Platelet Integrin αIIbβ3 Outside-in Signaling and Inhibits Thrombosis in Mice

Adaptor proteins play a critical role in the assembly of signaling complexes after engagement of platelet receptors by agonists such as collagen, ADP and thrombin. Recently, using proteomics, the Dok (downstream of tyrosine kinase) adapter proteins were identified in human and mouse platelets. In vi...

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Bibliografiske detaljer
Udgivet i:Thromb Haemost
Main Authors: Niki, Masaru, Nayak, Manasa K., Jin, Hong, Bhasin, Neha, Plow, Edward F., Pandolfi, Pier Paolo, Rothman, Paul B., Chauhan, Anil K., Lentz, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854776/
https://ncbi.nlm.nih.gov/pubmed/26790499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH15-05-0373
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