Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice

The capacity of pancreatic β cells to maintain glucose homeostasis during chronic physiologic and immunologic stress is important for cellular and metabolic homeostasis. Insulin receptor substrate 2 (IRS2) is a regulated adapter protein that links the insulin and IGF1 receptors to downstream signali...

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Publicado en:JCI Insight
Autores principales: Kuznetsova, Alexandra, Yu, Yue, Hollister-Lock, Jennifer, Opare-Addo, Lynn, Rozzo, Aldo, Sadagurski, Marianna, Norquay, Lisa, Reed, Jessica E., El Khattabi, Ilham, Bonner-Weir, Susan, Weir, Gordon C., Sharma, Arun, White, Morris F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854304/
https://ncbi.nlm.nih.gov/pubmed/27152363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.80749
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