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Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis()
Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to central metabolic sensing, partially by acting in leptin receptor (LepRb)-expressi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929908/ https://ncbi.nlm.nih.gov/pubmed/24567904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2013.10.004 |
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