IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action

Irs2-mediated insulin/IGF1 signaling in the CNS modulates energy balance and glucose homeostasis; however, the site for Irs2 function is unknown. The hormone leptin mediates energy balance by acting on leptin receptor (LepR-b)-expressing neurons. To determine whether LepR-b neurons mediate the metab...

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Autori principali: Sadagurski, Marianna, Leshan, Rebecca L., Patterson, Christa, Rozzo, Aldo, Kuznetsova, Alexandra, Skorupski, Josh, Jones, Justin C., Depinho, Ronald A., Myers, Martin G., White, Morris F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361909/
https://ncbi.nlm.nih.gov/pubmed/22560222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.04.011
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