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IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action
Irs2-mediated insulin/IGF1 signaling in the CNS modulates energy balance and glucose homeostasis; however, the site for Irs2 function is unknown. The hormone leptin mediates energy balance by acting on leptin receptor (LepR-b)-expressing neurons. To determine whether LepR-b neurons mediate the metab...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361909/ https://ncbi.nlm.nih.gov/pubmed/22560222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.04.011 |
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