MAFA and T(3) Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC

CONTEXT: Human embryonic stem cells (hESCs) differentiated toward β-cells and fetal human pancreatic islet cells resemble each other transcriptionally and are characterized by immaturity with a lack of glucose responsiveness, low levels of insulin content, and impaired proinsulin-to-insulin processi...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Aguayo-Mazzucato, Cristina, DiIenno, Amanda, Hollister-Lock, Jennifer, Cahill, Christopher, Sharma, Arun, Weir, Gordon, Colton, Clark, Bonner-Weir, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596039/
https://ncbi.nlm.nih.gov/pubmed/26207953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-2632
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