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Expression of MafA in pancreatic progenitors is detrimental for pancreatic development
The transcription factor MafA regulates glucose-responsive expression of insulin. MafA-deficient mice have a normal proportion of insulin(+) cells at birth but develop diabetes gradually with age, suggesting that MafA is required for maturation and not specification of pancreatic β-cells. However, s...
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| Asıl Yazarlar: | , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737322/ https://ncbi.nlm.nih.gov/pubmed/19576197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.06.029 |
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